Comparison of the Anti-inflammatory Efficacy of Chondroitin Sulphate and Diclofenac Sodium on Patients with Knee Osteoarthritis.
Morreale et al, Journal of Rheumatology Vol. 23: No.8, Aug 1996.
The researchers used a randomised, multicentre, double-blind trial to compare the anti-inflammatory efficacies of chondroitin sulphate (CS) and the NSAID diclofenac sodium (DS) in patients with knee osteoarthritis.
Glucosamine, Chondroitin, and Manganese Ascorbate for Degenerative Joint Disease of the Knee or Low Back:
A Randomised, Double-Blind, Placebo-Controlled Pilot Study.
Leffler C T, et al, Military
Medicine, Vol. 164, February 1999.
Sixteen-week randomised, double-blind, placebo-controlled crossover study design was implemented. Thirty-four males from the US Navy diving and special warfare community with pain and radiographic cartilage degeneration of the knee or low back were randomised into two groups, intervention (CosaminĘDS) and placebo. A summary score incorporated results of pain and functional questionnaires, physical examination scores and running times. Changes were presented as a percentage of the patient's average score. The authors reported significant improvement among patients in the knee intervention group in comparison the placebo group.
Efficacy of a Combination of FCHG49 Glucosamine Hydrochloride, TRHI22 Low Molecular Weight Sodium Chondroitin Sulfate and Manganese Ascorbate in the Management of Knee Osteoarthritis.
Das AK, Hammad TA.
Osteoarthritis and Cartilage, 2000.
A double-blind placebo-controlled study recruited 93 patients with cartilage degeneration of the knee from a single center. Patients were randomized into two group, intervention (CosaminDS) and placebo and were evaluated initially and then every two months for six months. The authors reported that patients with mild or moderate radiographic changes showed significant improvement at four and six months in comparison to the placebo group.
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Role of Glucosamine/Chondroitin Sulphate Formula in Treatment of an Osteochondral Impaction Injury in a Collegiate Basketball Player.
Schenck RC, Clare DJ, Gilley JS et al.
Orthopaedic Technology Review, 2(7):12-15, July/August, 2000.
Case history with repeat MRI and CT bone scans support that patients sustaining osteochondral impaction injury could benefit from CosaminĘDS administration.
